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Highly Selective Primary Alkoxycarboxylation and Esterification of Unprotected Pyranose Derivatives Mediated by Scandium(III) Triflate Catalysis (Eur. J. Org. Chem. 19/2012)
Author(s) -
McClure Michael S.,
Berry Malcolm B.,
Caine Darren,
Crawford Claire,
Crump Brian C.,
Glover Bobby N.,
Kedia Sandeep B.,
Millar Alan,
Mitchell Mark B.,
Nichols Christopher J.,
Patterson Daniel E.,
Powers Jeremiah
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201290048
Subject(s) - chemistry , pyranose , scandium , trifluoromethanesulfonate , catalysis , medicinal chemistry , organic chemistry
The cover picture shows the highly selective scandium‐catalyzed alkoxycarboxylation of an unprotected pyranose. The utility of this highly selective reaction is illustrated by the background photo of a 50 L reactor where the catalysis was carried out on a kilogram scale in Research Triangle Park, NC. The reaction scope and mechanistic details are described in the Short Communication by M. S. McClure et. al. on p. 3561 ff.