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Stereocontrol with Lithium Trimethylzincate toward Gibberellin Synthesis (Eur. J. Org. Chem. 11/2012)
Author(s) -
Isobe Minoru,
Chiang ChingTe,
Tsao KuoWei,
Cheng ChiaYi,
Bruening Reimar
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201290024
Subject(s) - chemistry , lithium (medication) , ring (chemistry) , zincate , conjugate , gibberellin , combinatorial chemistry , nanotechnology , stereochemistry , zinc , organic chemistry , medicine , mathematical analysis , materials science , mathematics , biology , endocrinology , genetics
The cover picture shows the North Gate of Hsinchu City, Taiwan, which has been preserved as a historical heritage site of the city, surrounded by modern electronic devices. The molecules shown include the synthesis of the A‐ring substructure of gibberellin, a plant hormone. The key reaction, the ability of lithium trimethylzincate to undergo conjugate addition, as discovered in 1977, was developed for the synthesis of the A‐ring in collaboration with Dr. Reimar Bruening in Nagoya University around 1980 (unpublished). Now, in 2012, this zincate chemistry has been used as the indispensable step at National Tsing Hua University. Zinc chemistry is surrounded by modern synthetic devices. Details are presented in the Short Communication by M. Isobe et al. on p. 2109 ff. Chia‐Yi Cheng is acknowledged for her help in designing this cover picture.