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Syntheses of Hydrazino Peptides and Conjugates
Author(s) -
Panda Siva S.,
ElNachef Claudia,
Bajaj Kiran,
Katritzky Alan R.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201731
Subject(s) - chemistry , nucleophile , conjugate , microwave irradiation , dipeptide , combinatorial chemistry , peptide , organic chemistry , stereochemistry , catalysis , biochemistry , mathematical analysis , mathematics
(α‐Benzyloxycarbonyl‐aminoacyl)benzotriazolides (Cbz = benzyloxycarbonyl) underwent a coupling reaction with α‐hydrazino acids under microwave irradiation to form hybrid hydrazino dipeptides (42–71 %). Chiral acylations of β‐ N ‐Cbz‐α‐hydrazino acylbenzotriazolides were successfully carried out with N ‐ , S‐, O‐, and C‐nucleophiles in yields of 49–88 %.