Syntheses of Hydrazino Peptides and Conjugates | Zendy

Panda Siva S. | Zendy; ElNachef Claudia | Zendy; Bajaj Kiran | Zendy; Katritzky Alan R. | Zendy

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Syntheses of Hydrazino Peptides and Conjugates

Author(s) -

Panda Siva S.,

ElNachef Claudia,

Bajaj Kiran,

Katritzky Alan R.

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201731

Subject(s) - chemistry , nucleophile , conjugate , microwave irradiation , dipeptide , combinatorial chemistry , peptide , organic chemistry , stereochemistry , catalysis , biochemistry , mathematical analysis , mathematics

(α‐Benzyloxycarbonyl‐aminoacyl)benzotriazolides (Cbz = benzyloxycarbonyl) underwent a coupling reaction with α‐hydrazino acids under microwave irradiation to form hybrid hydrazino dipeptides (42–71 %). Chiral acylations of β‐ N ‐Cbz‐α‐hydrazino acylbenzotriazolides were successfully carried out with N ‐ , S‐, O‐, and C‐nucleophiles in yields of 49–88 %.

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