Chiral α‐Arylethanamines: An Organocatalyst for the Enantioselective α‐Amination of Branched Aldehydes | Zendy

Fu JiYa | Zendy; Wang QiLin | Zendy; Peng Lin | Zendy; Gui YongYuan | Zendy; Wang Fan | Zendy; Tian Fang | Zendy; Xu XiaoYing | Zendy; Wang LiXin | Zendy

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Chiral α‐Arylethanamines: An Organocatalyst for the Enantioselective α‐Amination of Branched Aldehydes

Author(s) -

Fu JiYa,

Wang QiLin,

Peng Lin,

Gui YongYuan,

Wang Fan,

Tian Fang,

Xu XiaoYing,

Wang LiXin

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201701

Subject(s) - chemistry , enantioselective synthesis , amination , organocatalysis , organic chemistry , reductive amination , catalysis

α‐Arylethanamines were investigated as organocatalysts for the α‐amination of branched aldehydes with azodicarboxylates. Optimization identified ( R )‐1‐(1‐naphthyl)ethanamine ( 1g ) as an effective and enantioselective organocatalyst; multifunctional chiral quaternary amino aldehydes were successfully obtained in excellent yields (up to 99 %) and with excellent enantioselectivities (up to 98 % ee ).

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