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Henry Reaction in Aqueous Media at Neutral pH
Author(s) -
Bora Pranjal P.,
Bez Ghanashyam
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201682
Subject(s) - chemistry , nitro , phosphate buffered saline , aqueous medium , aqueous solution , organic chemistry , alcohol , phosphate , chromatography , alkyl
An efficient method for the synthesis of β‐nitro alcohols from nitro alkanes and aldehydes in aqueous phosphate buffer under neutral pH conditions at room temperature is reported. In the case of higher nitro alkanes, the reaction showed very good diastereoselectivity to give syn β‐nitro alcohols in preference to their anti products.