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Synthesis of Photoreactive 2‐Phenethylamine Derivatives – Synthesis of Adenosine Derivatives Enabling Functional Analysis of Adenosine Receptors by Photoaffinity Labeling
Author(s) -
Murai Yuta,
Masuda Katsuyoshi,
Ogasawara Yui,
Wang Lei,
Hashidoko Yasuyuki,
Hatanaka Yasumaru,
Iwata So,
Kobayashi Takuya,
Hashimoto Makoto
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201657
Subject(s) - chemistry , photoaffinity labeling , adenosine , adenosine receptor , azide , receptor , stereochemistry , biochemistry , combinatorial chemistry , agonist , organic chemistry
2‐Phenylethylamine is well known as a substructure of many biologically active compounds, and the synthesis of its photoreactive derivatives to allow the analysis of biological functions is reported. This allowed us to synthesise ligands for adenosine receptors, which have many functional roles in biology and have been extensively studied for their many roles in maintaining homeostasis. Adenosine is one of the most common biochemical compounds, but photoaffinity labeling has not yet been used to study adenosine receptors. Synthetic methods for producing photoreactive adenosine derivatives that can be used with adenosine receptors were established for the photophores phenyl azide and benzophenone. The effect of the introduction of the photoreactive components was determined using an adenosine receptor assay.