Premium
A Telescoping Synthesis of Chimeric Polyheterocycles through a Piperidine‐Mediated Multicomponent Reaction
Author(s) -
Lee ChiaHsin,
Hsu WeiShun,
Chen ChihHau,
Sun ChungMing
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201645
Subject(s) - piperidine , chemistry , stereochemistry , combinatorial chemistry
A new piperidine‐catalyzed Groebke–Bienaymé–Blackburn (GBB) multicomponent reaction of 2‐aminobenzimidazoles, methyl 2‐formylbenzoate, and isocyanides has been explored. A facile and straightforward postmodification leads to isoquinolinone‐embedded imidazo[1,2‐ a ]benzimidazoles. Insight into a plausible mechanism is discussed and supported by X‐ray crystal structure analysis.