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Synthesis of 1,2‐Diaryl‐1 H ‐indol‐4‐ols and 1,2‐Diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones from Arylglyoxals and Enamines through Domino Reactions
Author(s) -
Maity Subhendu,
Pathak Sudipta,
Pramanik Animesh
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201616
Subject(s) - chemistry , aromatization , domino , acetonitrile , medicinal chemistry , aryl , nucleophile , annulation , organic chemistry , catalysis , alkoxy group , alkyl
A series of 1,2‐diaryl‐ and 1‐alkyl‐2‐aryl‐1 H ‐indol‐4‐ols and 1,2‐diaryl‐7‐ethoxy‐1,5,6,7‐tetrahydroindol‐4‐ones have been prepared by the domino reactions of arylglyoxals and enamines at reflux in non‐nucleophilic and nucleophilic solvents such as acetonitrile and ethanol, respectively. The transformation occurs by annulation followed by aromatization without the use of any metal or catalyst.