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Diversely Substituted Triazolo[1,5‐ a ][1,4]benzodiazepinones: A Post‐Ugi Copper‐Catalyzed Tandem Azide–Alkyne Cycloaddition/Ullmann C–N Coupling Approach
Author(s) -
Vachhani Dipak D.,
Kumar Amit,
Modha Sachin G.,
Sharma Sunil K.,
Parmar Virinder S.,
Van der Eycken Erik V.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201587
Subject(s) - cycloaddition , chemistry , alkyne , tandem , azide , catalysis , copper , combinatorial chemistry , stereochemistry , organic chemistry , materials science , composite material
A diversity‐oriented approach comprising an Ugi 4‐component reaction and a copper‐catalyzed tandem azide–alkyne cycloaddition/Ullmann C–N coupling is elaborated. The methodology is compatible with various functional groups and allows the construction of triazolo[1,5‐ a ][1,4]benzodiazepinones in good yields.