Premium
Regio‐ and Stereoselective Olefination of Phenol Carbamates through C–H Bond Functionalization
Author(s) -
Li Bin,
Ma Jianfeng,
Liang Yujie,
Wang Nuancheng,
Xu Shansheng,
Song Haibin,
Wang Baiquan
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201574
Subject(s) - chemistry , carbamate , stereoselectivity , alkyne , phenol , ruthenium , rhodium , catalysis , surface modification , organic chemistry , combinatorial chemistry , medicinal chemistry
Two pathways that can be used to access ortho ‐olefinated phenol carbamate, including a ruthenium(II)‐catalyzed oxidative olefination of phenol carbamate with acrylates and a rhodium(III)‐catalyzed alkyne hydroarylation of phenol carbamate with internal alkynes through direct C–H activation, are reported. Both reactions afford substituted alkenes in a highly regio‐ and stereoselective manner.