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Copper‐Catalyzed Oxidative Coupling of Carboxylic Acids with N , N ‐Dialkylformamides: An Approach to the Synthesis of Amides
Author(s) -
Kumar P. Santhosh,
Kumar G. Sathish,
Kumar R. Arun,
Reddy N. Veera,
Rajender Reddy K.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201544
Subject(s) - chemistry , oxidative coupling of methane , amide , catalysis , copper , coupling (piping) , oxidative phosphorylation , peptide bond , carboxylic acid , amino acid , organic chemistry , combinatorial chemistry , stereochemistry , biochemistry , mechanical engineering , engineering
Abstract A new synthetic approach for amide bond formation through the oxidative coupling of N , N ‐dialkylformamides with carboxylic acids was achieved by using a copper catalyst. Furthermore, this method was applied in the coupling of chiral amino acids in which the stereochemistry was retained in the resulting amide products.