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Synthesis of β‐Substituted Porphyrin Derivatives Containing Heterocyclic Moieties as Potential Photosensitizers Against Cutaneous Leishmaniasis
Author(s) -
Bastos Mônica M.,
Gomes Ana T. P. C.,
Neves Maria G. P. M. S.,
Silva Artur M. S.,
SantosFilho Osvaldo A.,
Boechat Núbia,
Cavaleiro José A. S.
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201501
Subject(s) - chemistry , porphyrin , singlet oxygen , imine , combinatorial chemistry , stereochemistry , amine gas treating , organic chemistry , oxygen , catalysis
This work reports the synthesis of porphyrin derivatives with potential leishmanicidal activity. The β‐substituents contain amine/imine‐heterocyclic features. Molecular docking simulations of these compounds to a model of the enzyme arginase from Leishmania amazonensis were carried out. Singlet oxygen generation studies have been also considered. The obtained leishmanicidal properties show that these compounds can be considered as prototypes for future cutaneous antileishmaniasis agents.