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Ruthenium‐Catalyzed Selective Aerobic Oxidative ortho ‐Alkenylation of Substituted Phenols with Alkenes through C–H Bond Activation
Author(s) -
Reddy Mallu Chenna,
Jeganmohan Masilamani
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201463
Subject(s) - chemistry , alkene , catalysis , acrylonitrile , medicinal chemistry , ruthenium , phenols , organic chemistry , copolymer , polymer
The oxidative coupling of phenyl carbamates and acetates with alkenes in the presence of a catalytic amount of [RuCl 2 ( p ‐cymene)] 2 , AgSbF 6 , and Cu(OAc) 2 · H 2 O under air provided substituted alkene derivatives in a highly regio‐ and stereoselective manner. The catalytic reaction was compatible with various alkenes such as acrylates, vinyl sulfones, acrylonitrile, and substituted styrenes. The present catalytic reaction was also compatible with phenyl carbamates and acetates with various electron‐rich, electron‐deficient, and halogen substituents on the aromatic ring. Further examination of the catalytic reaction was done with the substituted phenyl acetates. By using LiOH · H 2 O or K 2 CO 3 as a base, the substituted alkene derivatives were converted into the corresponding phenol derivatives. To account for the catalytic reaction, a possible mechanism is proposed that involves a six‐membered ruthenacycle as the key intermediate.