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Carbohydrate‐Based Molecules for Molecular Imaging in Nuclear Medicine
Author(s) -
Ribeiro Morais Goreti,
Falconer Robert A.,
Santos Isabel
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201457
Subject(s) - radiosynthesis , chemistry , molecular imaging , nuclear imaging , pet imaging , nuclear medicine , positron emission tomography , radiochemistry , medicine , microbiology and biotechnology , biology , in vivo
This review covers published literature describing the synthesis of labeled carbohydrates for use in molecular imaging, with a particular focus on the use of nuclear techniques (PET, SPECT). Recent advances in the radiosynthesis of [ 18 F]FDG (electrophilic vs. nucleophilic radiofluorinations), a PET radiotracer based on glucose and the most widely PET tracer currently in use for cancer and inflammatory disease diagnosis, is considered. The powerful impact of [ 18 F]FDG in the clinic has prompted intensive research efforts into glucose‐based radiotracers for PET and SPECT imaging. These achievements are also reviewed, along with the use of glycopeptides for nuclear molecular imaging. Finally, recent work on the radionuclide labeling of nucleosides and glycoconjugates is discussed.