Asymmetric Organocatalytic 1,4‐Addition Reactions Starting from Enals with  gem ‐Difluoroalkyl Side Chains | Zendy

Khalaf Ali | Zendy; Grée Danielle | Zendy; Abdallah Hassan | Zendy; Jaber Nada | Zendy; Hachem Ali | Zendy; Grée René | Zendy

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Asymmetric Organocatalytic 1,4‐Addition Reactions Starting from Enals with gem ‐Difluoroalkyl Side Chains

Author(s) -

Khalaf Ali,

Grée Danielle,

Abdallah Hassan,

Jaber Nada,

Hachem Ali,

Grée René

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201427

Subject(s) - chemistry , organocatalysis , side chain , catalysis , enantioselective synthesis , organic chemistry , ether , combinatorial chemistry , stereochemistry , polymer

gem ‐Difluoroenals are excellent substrates for asymmetric organocatalytic 1,4‐additions of thiols and anilines. By using diarylsilylprolinol ether as a catalyst, good to excellent yields with ee values in the same range (up to 98 %) were obtained. The CF 2 R group strongly activates the enals towards these organocatalytic additions.

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