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Dilobenol A–G, Diprenylated Dihydroflavonols from the Leaves of Dilobeia thouarsii
Author(s) -
Razafintsalama Vahinalahaja,
Girardot Marion,
Randrianarivo Ranjana,
Rakoto Danielle,
Sarter Samira,
Petit Thomas,
Ralambonirina Sylvia,
Deville Alexandre,
Grellier Philippe,
Jeannoda Victor,
Mambu Lengo
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201421
Subject(s) - staphylococcus aureus , plasmodium falciparum , antibacterial activity , microbiology and biotechnology , vibrio , isolation (microbiology) , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , chemistry , biology , bacteria , traditional medicine , medicine , malaria , genetics , immunology
The study of the EtOAc extract of the leaves of Dilobeia thouarsii led to the isolation and identification of seven new diprenylated dihydroxyflavonols named dilobenol A–G ( 1–7 ). Their structures were elucidated by spectroscopic analysis including UV, IR, 1D and 2D NMR and MS as well as by chemical hydrolysis. The isolated compounds were assessed for their antibacterial, antiplasmodial and cytotoxic activities. They exhibited moderate growth inhibitory activities against Staphylococcus aureus, Vibrio spp., Bacillus spp, and Plasmodium falciparum without significant toxicity against mammalian cell line L‐6.