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Selectively Functionalized Constrained Polyazamacrocycles: Building Blocks for Multifunctional Chelating Agents
Author(s) -
Désogère Pauline,
Bernhard Claire,
Goze Christine,
Penouilh MarieJosé,
Rousselin Yoann,
Denat Franck
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201337
Subject(s) - chemistry , aminal , regioselectivity , bifunctional , chelation , combinatorial chemistry , carbon skeleton , stereochemistry , polymer chemistry , organic chemistry , catalysis
A new class of cross‐bridged and side‐bridged 1,4,7,10‐tetraazacyclotridecanes (homocyclens) bearing an aminomethyl pendant arm on the carbon skeleton has been prepared. The regioselectivity of the quaternization of the bis‐aminal intermediates is discussed on the basis of X‐ray diffraction and NMR experiments. These new polyazamacrocycles are valuable precursors of bifunctional chelating agents for applications in nuclear medicine.