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Protoporphyrin IX/Cobyrinate Derived Hybrids – Novel Activators of Soluble Guanylyl Cyclase
Author(s) -
Chromiński Mikołaj,
ó Proinsias Keith,
Martin Emil,
Gryko Dorota
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201303
Subject(s) - chemistry , protoporphyrin ix , soluble guanylyl cyclase , linker , cycloaddition , gucy2d , azide , combinatorial chemistry , guanylate cyclase , alkyne , small molecule , catalysis , stereochemistry , biochemistry , organic chemistry , guanylate cyclase 2c , photodynamic therapy , enzyme , computer science , operating system
Abstract Cobyrinate/protoporphyrin IX molecular hybrids were prepared through application of the CuOAc catalyzed azide‐alkyne cycloaddition (CuAAC) "click" reaction. The synthesis involved selective preparation of cobyrinate and PpIX derived building blocks possessing respectively terminal alkyne and azide moieties, followed by a CuOAc catalyzed cycloaddition reaction. Synthesized molecules activated soluble guanylyl cyclase and showed strong linker‐length/activation dependence.