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Silver‐Catalyzed Cyclization of N ‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines
Author(s) -
Chioua Mourad,
Soriano Elena,
Infantes Lourdes,
Jimeno M. Luisa,
MarcoContelles José,
Samadi Abdelouahid
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201258
Subject(s) - chemistry , cycloisomerization , isomerization , regioselectivity , catalysis , pyridine , medicinal chemistry , combinatorial chemistry , organic chemistry
We report herein the silver‐catalyzed cycloisomerization of readily available N ‐(prop‐2‐yn‐1‐yl)pyridine‐2‐amines as a new and practical method for the synthesis of differently substituted 3‐methylimidazo[1,2‐ a ]pyridines. The isomerization reactions proceeded under mild reactions conditions to give good yields and excellent regioselectivity. A DFT‐based mechanistic analysis is also reported.