Silver‐Catalyzed Cyclization of  N ‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines | Zendy

Chioua Mourad | Zendy; Soriano Elena | Zendy; Infantes Lourdes | Zendy; Jimeno M. Luisa | Zendy; MarcoContelles José | Zendy; Samadi Abdelouahid | Zendy

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Silver‐Catalyzed Cyclization of N ‐(Prop‐2‐yn‐1‐yl)pyridin‐2‐amines

Author(s) -

Chioua Mourad,

Soriano Elena,

Infantes Lourdes,

Jimeno M. Luisa,

MarcoContelles José,

Samadi Abdelouahid

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201258

Subject(s) - chemistry , cycloisomerization , isomerization , regioselectivity , catalysis , pyridine , medicinal chemistry , combinatorial chemistry , organic chemistry

We report herein the silver‐catalyzed cycloisomerization of readily available N ‐(prop‐2‐yn‐1‐yl)pyridine‐2‐amines as a new and practical method for the synthesis of differently substituted 3‐methylimidazo[1,2‐ a ]pyridines. The isomerization reactions proceeded under mild reactions conditions to give good yields and excellent regioselectivity. A DFT‐based mechanistic analysis is also reported.

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