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Gold‐Catalyzed Mannich Addition Reactions of 1,3‐Dicarbonyl Compounds with N ‐Protected Imines
Author(s) -
DelgadoRebollo Manuela,
Moreno Rocio,
Fructos Manuel R.,
Prieto Auxiliadora
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201252
Subject(s) - chemistry , catalysis , carbene , mannich reaction , organic chemistry , medicinal chemistry , combinatorial chemistry
The first (N‐heterocyclic carbene)Au I ‐catalyzed Mannich addition reactions of N ‐protected imines with different 1,3‐dicarbonyl compounds are described. IPrAuNTf 2 was proven to be an efficient catalyst for the reactions of β‐keto esters and 1,3‐diketones with N ‐sulfonylimines to afford the desired β‐amino carbonyl compounds in good yields under very mild conditions.