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Highly Efficient Construction of Trifluoromethylated Heterocycles; [3+2] Annulation of N,N′‐Cyclic or C,N‐Cyclic Azomethine Imines with Trifluoromethyl‐Containing Electron‐Deficient Olefins
Author(s) -
Wang De,
Deng HongPing,
Wei Yin,
Xu Qin,
Shi Min
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201244
Subject(s) - chemistry , trifluoromethyl , annulation , stereoselectivity , medicinal chemistry , organic chemistry , stereochemistry , catalysis , alkyl
A highly regio‐ and stereoselective synthesis of pyrazolidine analogues by the use of N,N′‐cyclic or C,N‐cyclic azomethine imines with two different trifluoromethyl‐containing olefins has been developed. The method affords highly functionalized trifluoromethyl‐containing pyrazolidine analogues in excellent yields with high diastereoselectivities under mild conditions.