Highly Efficient Construction of Trifluoromethylated Heterocycles; [3+2] Annulation of N,N′‐Cyclic or C,N‐Cyclic Azomethine Imines with Trifluoromethyl‐Containing Electron‐Deficient Olefins | Zendy

Wang De | Zendy; Deng HongPing | Zendy; Wei Yin | Zendy; Xu Qin | Zendy; Shi Min | Zendy

Premium

Highly Efficient Construction of Trifluoromethylated Heterocycles; [3+2] Annulation of N,N′‐Cyclic or C,N‐Cyclic Azomethine Imines with Trifluoromethyl‐Containing Electron‐Deficient Olefins

Author(s) -

Wang De,

Deng HongPing,

Wei Yin,

Xu Qin,

Shi Min

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201244

Subject(s) - chemistry , trifluoromethyl , annulation , stereoselectivity , medicinal chemistry , organic chemistry , stereochemistry , catalysis , alkyl

A highly regio‐ and stereoselective synthesis of pyrazolidine analogues by the use of N,N′‐cyclic or C,N‐cyclic azomethine imines with two different trifluoromethyl‐containing olefins has been developed. The method affords highly functionalized trifluoromethyl‐containing pyrazolidine analogues in excellent yields with high diastereoselectivities under mild conditions.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research