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Chitosan Aerogel Beads as a Heterogeneous Organocatalyst for the Asymmetric Aldol Reaction in the Presence of Water: An Assessment of the Effect of Additives
Author(s) -
Gioia Claudio,
Ricci Alfredo,
Bernardi Luca,
Bourahla Khadidja,
Tanchoux Nathalie,
Robitzer Mike,
Quignard Françoise
Publication year - 2013
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201187
Subject(s) - chemistry , aldol reaction , aerogel , chitosan , catalysis , ketone , organic chemistry , aldol condensation , organocatalysis , heterogeneous catalysis , combinatorial chemistry , enantioselective synthesis , chemical engineering , engineering
The catalytic properties of chitosan aerogel for the direct asymmetric aldol reaction in water assisted by various surfactants and acid co‐catalysts have been evaluated by employing a range of donor and acceptor systems. A beneficial effect on both the yields and enantioselectivities was observed, and the combination of surfactants and acid co‐catalysts has proven particularly useful in the case of heterocyclic ketone donors.