Diversely Substituted Imidazo[1,2‐ a ]pyrazine‐8‐oxo‐3‐carbaldehydes: An Iodine‐Mediated Cyclization/Oxidation Approach | Zendy

Mishra Nigam M. | Zendy; Vachhani Dipak D. | Zendy; Modha Sachin G. | Zendy; Van der Eycken Erik V. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Diversely Substituted Imidazo[1,2‐ a ]pyrazine‐8‐oxo‐3‐carbaldehydes: An Iodine‐Mediated Cyclization/Oxidation Approach

Author(s) -

Mishra Nigam M.,

Vachhani Dipak D.,

Modha Sachin G.,

Van der Eycken Erik V.

Publication year - 2013

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201150

Subject(s) - chemistry , alkyne , amination , intramolecular force , combinatorial chemistry , pyrazine , iodine , catalysis , organic chemistry

A mild and efficient iodine‐mediated intramolecular heteroannulation approach for the construction of the imidazo[1,2‐ a ]pyrazinone core has been developed. Under ambient conditions, this metal‐free protocol allows easy access to densely functionalized imidazo[1,2‐ a ]pyrazinone‐3‐carbaldehydes or (aminomethyl)imidazo[1,2‐ a ]pyrazinones from substrates containing terminal alkynes by cyclization and subsequent oxidation or amination. Further diversification may be introduced by using substrates containing an internal alkyne and/or Suzuki coupling after cyclization to generate polysubstituted (dihydro)imidazo[1,2‐ a ]pyrazinones.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research