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Combined Pd/C and Montmorillonite Catalysis for One‐Pot Synthesis of Benzimidazoles
Author(s) -
Weires Nicholas A.,
Boster Jared,
Magolan Jakob
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201201101
Subject(s) - chemistry , montmorillonite , dehydrogenation , catalysis , condensation , antifungal , one pot synthesis , organic chemistry , combinatorial chemistry , heterogeneous catalysis , physics , thermodynamics , medicine , dermatology
A series of nineteen benzimidazoles were prepared from ortho ‐nitroanilines by one‐pot transfer hydrogenation, condensation, and dehydrogenation enabled by the concurrent use of two heterogeneous catalysts: montmorillonite‐K10 and Pd/C. This strategy was further employed to accomplish a five‐step, three‐component synthesis of an antifungal benzimidazoquinazoline by using a simple one‐pot procedure.