Chemoselective Preparation of Unsymmetrical Bis(1,2,3‐triazole) Derivatives and Application in Bis(1,2,3‐triazole)‐Modified Peptidomimetic Synthesis | Zendy

Niu Tengfei | Zendy; Gu Lin | Zendy; Wang Liang | Zendy; Yi Wenbin | Zendy; Cai Chun | Zendy

Premium

Chemoselective Preparation of Unsymmetrical Bis(1,2,3‐triazole) Derivatives and Application in Bis(1,2,3‐triazole)‐Modified Peptidomimetic Synthesis

Author(s) -

Niu Tengfei,

Gu Lin,

Wang Liang,

Yi Wenbin,

Cai Chun

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201201096

Subject(s) - peptidomimetic , chemistry , cycloaddition , azide , combinatorial chemistry , triazole , bifunctional , alkyne , 1,2,3 triazole , click chemistry , organic chemistry , catalysis , peptide , biochemistry

An efficient chemoselective methodology for the syntheses of unsymmetrical bis(1,2,3‐triazole) derivatives has been developed. This protocol utilizes alkynyl‐substituted amines as bifunctional linkers to conjoin a copper‐free three‐component cycloaddition with a copper(I)‐catalyzed alkyne–azide cycloaddition in a one‐pot procedure. In addition, we used this method for the construction of unsymmetrical bis(1,2,3‐triazole)‐modified peptidomimetics through a combination of multicomponent reactions taking place in a sequential process, which may be utilized in biological applications.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research