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CuI/SnCl 2 Co‐Catalyzed Four‐Component Reaction of Ketones, Amines, Alkynes, and Carbon Dioxide
Author(s) -
Zhao Jinwu,
Huang Huawen,
Qi Chaorong,
Jiang Huanfeng
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200990
Subject(s) - chemistry , steric effects , catalysis , aryl , carbon dioxide , primary (astronomy) , component (thermodynamics) , medicinal chemistry , organic chemistry , alkyl , physics , astronomy , thermodynamics
The four‐component CuI and SnCl 2 co‐catalyzed assembly of ketones, amines, alkynes, and carbon dioxide could be performed in DMSO at 70 °C under CO 2 pressure to synthesize 5‐alkynlene oxazolidinones. It was found that steric hindrance had an extreme effect on the four‐component coupling. Aliphatic ketones, basic primary amines, and aryl alkynes were good substrates.