CuI/SnCl 2  Co‐Catalyzed Four‐Component Reaction of Ketones, Amines, Alkynes, and Carbon Dioxide | Zendy

Zhao Jinwu | Zendy; Huang Huawen | Zendy; Qi Chaorong | Zendy; Jiang Huanfeng | Zendy

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CuI/SnCl 2 Co‐Catalyzed Four‐Component Reaction of Ketones, Amines, Alkynes, and Carbon Dioxide

Author(s) -

Zhao Jinwu,

Huang Huawen,

Qi Chaorong,

Jiang Huanfeng

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201200990

Subject(s) - chemistry , steric effects , catalysis , aryl , carbon dioxide , primary (astronomy) , component (thermodynamics) , medicinal chemistry , organic chemistry , alkyl , physics , astronomy , thermodynamics

The four‐component CuI and SnCl 2 co‐catalyzed assembly of ketones, amines, alkynes, and carbon dioxide could be performed in DMSO at 70 °C under CO 2 pressure to synthesize 5‐alkynlene oxazolidinones. It was found that steric hindrance had an extreme effect on the four‐component coupling. Aliphatic ketones, basic primary amines, and aryl alkynes were good substrates.

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