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Construction of Chiral Multi‐Functionalized Polyheterocyclic Benzopyran Derivatives by Using an Asymmetric Organocatalytic Domino Reaction
Author(s) -
Guo ZhiWei,
Li XinSheng,
Zhu WeiDong,
Xie JianWu
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200928
Subject(s) - chemistry , enantioselective synthesis , bifunctional , benzopyran , domino , organocatalysis , cinchona , asymmetric carbon , combinatorial chemistry , cascade reaction , cinchona alkaloids , organic chemistry , catalysis , optically active
The asymmetric domino reaction of various α,α‐dicyano olefins to 3‐nitro‐2 H ‐chromenes was studied employing readily available cinchona‐derived bifunctional thioureas as organocatalysts. These new transformations were highly regio‐, chemo‐, diastereo‐, and enantioselective simultaneously giving chiral multi‐functionalized polyheterocyclic benzopyran derivatives with multi‐chiral carbon centers.