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Intermolecular Mono‐ and Dihydroamination of Activated Alkenes Using a Recoverable Gold Catalyst
Author(s) -
Medina Florian,
Michon Christophe,
AgbossouNiedercorn Francine
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200891
Subject(s) - hydroamination , chemistry , catalysis , intermolecular force , salt (chemistry) , organic chemistry , polymer chemistry , combinatorial chemistry , molecule
A combination of gold chloride organometallic complex and a silver salt was used to catalyze intermolecular hydroamination of activated alkenes, i.e aza‐Michael reactions. The gold‐catalyzed reactions of activated alkenes with nitrogen substrates were investigated and found to afford various mono‐ and dihydroamination products, the latter being rare and original. After flash chromatography, gold NHC catalyst could be recovered as a gold hydroxide NHC complex. When combined with a silver salt, the gold complex lead again to an active hydroamination catalyst.