Premium
Domino Reactions Initiated by Enantioselective Cu‐Catalyzed Conjugate Addition
Author(s) -
Galeštoková Zuzana,
Šebesta Radovan
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200875
Subject(s) - chemistry , enantioselective synthesis , domino , reagent , conjugate , electrophile , catalysis , combinatorial chemistry , halide , alkyl , organic chemistry , addition reaction , cascade reaction , mathematics , mathematical analysis
Enantioselective copper‐catalyzed 1,4‐additions of organometallic reagents are useful components of domino reactions. Enolates resulting from such additions readily react with a range of electrophilic reagents, such as aldehydes and acetals, alkyl and allyl halides and halide surrogates, epoxides, imines, nitroalkenes, and α,β‐unsaturated carbonyl compounds. The aim of this review is to give an overview of domino transformations based on Cu‐catalyzed conjugate addition. Special emphasis is placed on the most recent work and also on that utilized in the synthesis of complex target molecules.