Premium
Domino Benzylic‐Amination–Sonogashira–Heterocyclisation Reaction: Direct Access to Dipyrido[1,2‐ a :3′,4′‐ d ]imidazole Salts
Author(s) -
Henry Nicolas,
Thiery Emilie,
Petrignet Julien,
Halouchi Hassan,
Thibonnet Jérôme,
Abarbri Mohamed
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200856
Subject(s) - chemistry , imidazole , sonogashira coupling , amination , domino , combinatorial chemistry , scope (computer science) , cascade reaction , organic chemistry , medicinal chemistry , catalysis , palladium , computer science , programming language
A new one‐pot domino process, involving four chemical transformations, for the synthesis of new dipyrido[1,2‐ a :3′,4′‐ d ]imidazole salts in a multicomponent reaction is reported. Various dipyrido[1,2‐ a :3′,4′‐ d ]imidazoles were obtained in moderate to good yields. The scope and limitations of the process and the reaction mechanism are discussed.