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Diversity‐Oriented Synthesis of Spiro‐ and Fused Azacycles from Ketone Molecular Templates
Author(s) -
Maltais René,
Poirier Donald
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200852
Subject(s) - template , ketone , chemistry , chemical space , combinatorial chemistry , organic chemistry , nanotechnology , drug discovery , biochemistry , materials science
A new diversity‐oriented synthesis (DOS) methodology was developed to generate different types of azacycles (oxazinones, oxazolidinones, and morpholines) from β‐amino diols, which can be easily obtained from ketones. Considering the large number of natural products and synthetic templates bearing a ketone functionality, this DOS methodology opens the door to the exploration of chemical space regions around the ketone and will favor the discovery of bioactive compounds.