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One‐Pot, Three‐Component Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles Starting from Primary Alcohols
Author(s) -
Jin Guanyi,
Zhang Jian,
Fu Dan,
Wu Jingjing,
Cao Song
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200830
Subject(s) - chemistry , triethylamine , primary (astronomy) , cycloaddition , imidazole , sodium azide , methylene , iodide , organic chemistry , component (thermodynamics) , sodium iodide , halide , combinatorial chemistry , catalysis , physics , astronomy , thermodynamics
A novel, one‐pot, three‐component approach for the synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles through the cycloaddition of a wide range of primary alcohols with sodium azide and active methylene ketones in the presence of N ‐( p ‐toluenesulfonyl)imidazole, tetrabutylammonium iodide, and triethylamine in DMF/DMSO has been developed.