One‐Pot, Three‐Component Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles Starting from Primary Alcohols | Zendy

Jin Guanyi | Zendy; Zhang Jian | Zendy; Fu Dan | Zendy; Wu Jingjing | Zendy; Cao Song | Zendy

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One‐Pot, Three‐Component Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles Starting from Primary Alcohols

Author(s) -

Jin Guanyi,

Zhang Jian,

Fu Dan,

Wu Jingjing,

Cao Song

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201200830

Subject(s) - chemistry , triethylamine , primary (astronomy) , cycloaddition , imidazole , sodium azide , methylene , iodide , organic chemistry , component (thermodynamics) , sodium iodide , halide , combinatorial chemistry , catalysis , physics , astronomy , thermodynamics

A novel, one‐pot, three‐component approach for the synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles through the cycloaddition of a wide range of primary alcohols with sodium azide and active methylene ketones in the presence of N ‐( p ‐toluenesulfonyl)imidazole, tetrabutylammonium iodide, and triethylamine in DMF/DMSO has been developed.

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