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Synthesis of Tin‐Containing Cyclodextrins as Potential Enzyme Models
Author(s) -
Zhou You,
Marinescu Lavinia,
Pedersen Christian Marcus,
Bols Mikael
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200756
Subject(s) - chemistry , tin , cyclodextrin , yield (engineering) , macromolecule , polymer chemistry , organic chemistry , combinatorial chemistry , biochemistry , materials science , metallurgy
The synthesis and the characterization of two types of water‐soluble β‐cyclodextrin‐supported organotin derivatives is described. These new tin‐containing macromolecules were prepared through a free radical bishydrostannylation of the corresponding β‐cyclodextrin propargylic ethers using Me 2 SnClH prepared in situ with AIBN as initiator. The tin moieties were attached both on the primary and on the secondary rim of β‐cyclodextrin in excellent yield.