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Trideuteriomethoxylation of Aryl and Heteroaryl Halides
Author(s) -
Dash Pragyanditi,
Janni Manojkumar,
Peruncheralathan S.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200753
Subject(s) - chemistry , halide , aryl , denticity , catalysis , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , crystal structure , alkyl , receptor , biochemistry
Direct access to trideuteriomethoxylated aromatic and heteroaromatic compounds has been developed. Various aryl and heteroaryl halides underwent d 3 ‐methoxylation under mild reaction conditions by using a catalyst system composed of the commercially available monodentate phosphane ligand t BuXPhos and Pd(OAc) 2 . Inexpensive CD 3 OD served as an efficient trideuteriomethoxylating agent.