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Phosphane‐Catalyzed [4+2] Annulation of Allenoates with Ketimines: Synthesis of Sultam‐Fused Tetrahydropyridines
Author(s) -
Chen XiangYu,
Ye Song
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200747
Subject(s) - annulation , chemistry , regioselectivity , electrophile , catalysis , organic chemistry , organocatalysis , combinatorial chemistry , enantioselective synthesis
Cyclic ketimines were successfully used as electrophiles in phosphane‐catalyzed [4+2] annulation reactions with ethyl 2‐methyl‐2,3‐butadienoate to give the corresponding highly substituted tetrahydropyridine derivatives in moderate to good yields (55–73 %), and with moderate to excellent regioselectivity.