Premium
Total Synthesis of (±)‐Dysibetaine CPa and Analogs
Author(s) -
Oikawa Masato,
Sasaki Shota,
Sakai Michihiro,
Ishikawa Yuichi,
Sakai Ryuichi
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200730
Subject(s) - imide , chemistry , cyclopropanation , sponge , stereochemistry , ring (chemistry) , carboxylic acid , total synthesis , organic chemistry , catalysis , botany , biology
The syntheses of the marine sponge‐derived γ‐amino carboxylic acid dysibetaine CPa and five analogs in their racemic forms were successfully performed by taking advantage of an electron‐withdrawing N ‐(4‐nitrophenyl) group in the cyclopropanation reaction, the reductive ring opening of an imide, and the ethanolysis of an N ‐Boc‐protected imide.