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Versatile Synthesis of 1‐ O ‐(ω‐Aminolauryl)‐I(4,5)P 2
Author(s) -
Varvogli AnastasiaAikaterini C.,
Fylaktakidou Konstantina C.,
Farmaki Theodora,
Stefanakis John G.,
Koumbis Alexandros E.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200726
Subject(s) - chemistry , combinatorial chemistry , inositol , derivative (finance) , inositol phosphate , biochemistry , receptor , financial economics , economics
The synthesis of a model 1‐ O ‐(ω‐aminoacyl)‐IP 2 derivative, lauryl 4,5‐bisphosphate 31 , was realized following a versatile and high‐yielding scheme. The flexible synthetic strategy used for this purpose allows the preparation of a range of other useful IP, IP 2 and IP 3 derivatives. In view of the central role played by IPs and PIPs in cellular life, the preparation of functionalized myo ‐inositol derivatives of this type may facilitate the isolation and fluorescent localization of related proteins.