Practical Pd/C‐Catalysed Suzuki–Miyaura Reactions for the Preparation of 3‐Aryl‐4‐oxypyridin‐2(1 H )‐ones, 3‐Aryl‐2,4‐oxypyridines and 3‐Aryl‐2,4‐oxyquinolines as Useful Intermediates for the Synthesis of Biologically Active Compounds

Practical heterogeneous Pd/C‐catalysed Suzuki–Miyaura cross‐coupling reactions of 3‐iodo‐4‐oxypyridin‐2(1 H )‐ones, 3‐iodo‐2,4‐oxypyridines, and 3‐iodo‐2,4‐oxyquinolines with arylboronic acids are described as a useful and efficient alternative to homogeneous conditions. The methodology features ligand‐free and environmentally friendly conditions, and tolerates a wide range of boronic acids. The cross‐coupled products can be viewed as useful intermediates for the preparation of 3‐aryl‐4‐hydroxypyridin‐2(1 H )‐ones, which can be used as new nucleobases for antiherpetic agents.