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Regioselective N ‐Alkylation of 2‐Aminoimidazoles with Alcohols to 2‐( N ‐Alkylamino)imidazoles Catalyzed by the [Cp*IrCl 2 ] 2 /K 2 CO 3 System
Author(s) -
Li Feng,
Kang Qikai,
Shan Haixia,
Chen Lin,
Xie Jianjiang
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200698
Subject(s) - regioselectivity , chemistry , alkylation , iridium , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry
The direct N ‐alkylation of 2‐aminoimidazoles to give the corresponding 2‐( N ‐alkylamino)imidazoles was accomplished using alcohols as alkylating agents in the presence of a [Cp*IrCl 2 ] 2 /K 2 CO 3 system. The iridium‐catalyzed regioselective reaction is simple, efficient, general, and environmentally benign.
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