One‐Pot Synthesis of 3,5‐Disubstituted Isoxazoles from Propargylic Alcohols through Propargylic  N ‐Hydroxylamines | Zendy

Raji Reddy Chada | Zendy; Vijaykumar Jonnalagadda | Zendy; Jithender Enukonda | Zendy; Reddy Gangireddy Pavan Kumar | Zendy; Grée René | Zendy

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One‐Pot Synthesis of 3,5‐Disubstituted Isoxazoles from Propargylic Alcohols through Propargylic N ‐Hydroxylamines

Author(s) -

Raji Reddy Chada,

Vijaykumar Jonnalagadda,

Jithender Enukonda,

Reddy Gangireddy Pavan Kumar,

Grée René

Publication year - 2012

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201200628

Subject(s) - chemistry , one pot synthesis , combinatorial chemistry , catalysis , organic chemistry

An efficient approach has been described for the synthesis of 3,5‐disubstituted isoxazoles from propargylic alcohols. The strategy involves a one‐pot p ‐TSA‐catalyzed N ‐propargylation of protected hydroxylamines followed by a TBAF‐mediated detosylative 5‐ endo ‐ dig cyclization. The method was successfully used for the synthesis of various 3,5‐disubstituted isoxazoles.

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