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One‐Pot Sequential Synthesis of Ethers from an Aliphatic Carboxylic Acid and an Alcohol by Indium‐Catalyzed Deoxygenation of an Ester
Author(s) -
Sakai Norio,
Usui Yuta,
Moriya Toshimitsu,
Ikeda Reiko,
Konakahara Takeo
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200552
Subject(s) - deoxygenation , chemistry , alcohol , catalysis , carboxylic acid , indium , nitro , organic chemistry , halogen , alkyl
We have developed a widely applicable and direct method of etherification from a carboxylic acid and an alcohol by indium‐catalyzed deoxygenation of the transient ester formed in a one‐pot reaction. This simple catalytic reducing system appears to be remarkably tolerant of several functional groups including alkenes, halogens, nitro and heterocyclic groups.