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Synthesis of Flavones and γ‐Benzopyranones Using Mild Sonogashira Coupling and 18‐Crown‐6 Ether Mediated 6‐ endo Cyclization
Author(s) -
Chuang DaWei,
ElShazly Mohamed,
Balaji D. Barve,
Chung YuMing,
Chang FangRong,
Wu YangChang
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200529
Subject(s) - chemistry , sonogashira coupling , flavones , ether , halogen , crown ether , organic chemistry , combinatorial chemistry , alkyl , medicinal chemistry , catalysis , palladium , ion , chromatography
An efficient method for the synthesis of flavones and γ‐benzopyranones has been developed utilizing a mild Sonogashira coupling and 18‐crown‐6 ether mediated 6‐ endo cyclization of o ‐alkynoylphenyl acetates. By using this strategy, flavones and γ‐benzopyranones bearing electron‐donating groups, halogens, and simple alkyl substituents were synthesized in satisfactory yields.