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Electrophilic Cyclization of 2‐(2′,3′‐Allenyl)acetylacetates with Iodine Using Calcium Hydride as the Base
Author(s) -
Wan Baoqiang,
Jiang Xuefeng,
Jia Guochen,
Ma Shengming
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200527
Subject(s) - chemistry , electrophile , iodine , hydride , base (topology) , combinatorial chemistry , palladium , organic chemistry , catalysis , medicinal chemistry , metal , mathematical analysis , mathematics
A facile and efficient protocol for the synthesis of 4,5‐dihydrofuran derivatives via iodine‐mediated cyclization of various 2‐(2′,3′‐allenyl)acetylacetates with CaH 2 as the base has been developed. The yields range from moderate to good. The resulting products can be used for further elaboration by palladium‐catalyzed coupling reactions.