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Catalytic Asymmetric Addition of Alkyllithium Reagents to Aromatic Aldehydes
Author(s) -
FernándezMateos Emilio,
Maciá Beatriz,
Yus Miguel
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200464
Subject(s) - chemistry , reagent , alkylation , catalysis , organic chemistry , enantioselective synthesis , aldehyde , combinatorial chemistry
Herein, we report the first efficient catalytic system for the asymmetric alkylation of aldehydes with organolithium reagents in the presence of titanium(IV) isopropoxide. A variety of alkyllithium reagents can be added to aromatic aldehydes in good yields with high enantioselectivities in a simple one‐pot procedure under mild conditions.
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