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Ordered Mesoporous Proline Organocatalyst with High Activity and Strong Durability in Promoting Intermolecular Cross‐Conjugated Additions
Author(s) -
He Wenhan,
Zhang Fang,
Shi Xiaodong,
Li Hexing
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200396
Subject(s) - chemistry , catalysis , conjugated system , intermolecular force , organocatalysis , mesoporous material , combinatorial chemistry , heterogeneous catalysis , lewis acids and bases , durability , base (topology) , organic chemistry , polymer , chemical engineering , enantioselective synthesis , molecule , database , computer science , engineering , mathematical analysis , mathematics
A proline‐modified porous SBA‐15 was developed and applied as organocatalyst in promoting intermolecular conjugated addition between nitroalkenes and enones. This heterogeneous catalyst exhibited high efficiency and great durability toward the designated reaction, giving good to excellent yields even after multiple recycles (measured up to 7 times). By considering the unique Lewis‐base activation mechanism, the reported work supplies the platform to further investigate this new class of transformation by combining the benefits of both homogeneous catalysts for high catalytic efficiencies and heterogeneous catalysts for easy separation and reuse.