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Application of LB‐Phos·HBF 4 in the Suzuki Coupling Reaction of 2‐Bromoalken‐3‐ols with Alkylboronic Acids
Author(s) -
Guo Binjie,
Fu Chunling,
Ma Shengming
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200350
Subject(s) - chemistry , phos , suzuki reaction , alkyl , coupling reaction , coupling (piping) , medicinal chemistry , primary (astronomy) , organic chemistry , stereochemistry , catalysis , aryl , biochemistry , physics , astronomy , mechanical engineering , engineering
LB‐Phos · HBF 4 was used in the Suzuki coupling reaction of 2‐bromoalken‐3‐ols with alkylboronic acids to give the coupling products in moderate to good yields. Substituents such as benzyl, phenyl, allyl, and alkyl are tolerated at the 1‐ and 3‐positions of the 2‐bromoalken‐3‐ols. The reactions of both primary and secondary alkylboronic acids proceed smoothly.