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Microwave‐Assisted Formation of Peptide–Vitamin Conjugates
Author(s) -
ElNachef Claudia,
Bajaj Kiran,
Koblick Jacqueline,
Katritzky Alan R.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200323
Subject(s) - chemistry , conjugate , biotinylation , peptide , biotin , benzotriazole , microwave irradiation , vitamin , microwave chemistry , combinatorial chemistry , amino acid , stereochemistry , biochemistry , organic chemistry , catalysis , mathematical analysis , mathematics
Amino acid and peptide conjugates with vitamin B 3 , H, E and D 3 were synthesized by using microwave irradiation in good to satisfactory yields. In addition, a novel benzotriazole‐activated biotin intermediate has been introduced, which could serve as an alternative biotinylation agent.