Premium
Synthesis of Cholic Acid Oligomer–Taurine Conjugates: A Study of Their Aggregation and Cholesterol Solubilization
Author(s) -
Satyanarayana T. B. N.,
Maitra Uday,
Savyasachi A. J.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200312
Subject(s) - cholic acid , chemistry , micelle , taurine , oligomer , dynamic light scattering , solubilization , conjugate , cholesterol , aqueous solution , organic chemistry , biochemistry , amino acid , nanoparticle , chemical engineering , engineering , mathematical analysis , mathematics
Taurine conjugates of two cholic acid derived oligomers with different spacers between the cholic acid units were synthesized. These molecules self‐assemble in aqueous media. The critical micelle concentration (CMC) values were measured by using fluorescence spectroscopic analysis and the aggregates were characterized by dynamic light scattering and electron microscopy. The cooperativity of the cholic acid units in these tetramers to solubilize cholesterol was investigated. The ability of these molecules to act as nanocarriers for liphophilic dyes was also studied.