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Total Syntheses of (–)‐α‐Kainic Acid
Author(s) -
Stathakis Christos I.,
Yioti Efthymia G.,
Gallos John K.
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200243
Subject(s) - kainic acid , chemistry , amino acid , stereochemistry , biochemistry , receptor , glutamate receptor
Kainoid amino acids are a unique group of non‐proteinogenic pyrrolidinedicarboxylic acids. The parent member, (–)‐α‐kainic acid (originally known as digenic acid), has attracted considerable interest, largely because of its neuroexcitatory properties, as well as its pronounced insecticidal and anthelmitic activities. Because these activities are strongly due to its stereochemistry, (–)‐α‐kainic acid represents a considerable synthetic challenge, and many groups have therefore reported syntheses of kainic acids, as well as of kainoid analogues. This article is intended to review the total synthesis of kainic acid from 1996 until the end of 2011.