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1 H ‐Isoindole‐Based Potential Peptidomimetics
Author(s) -
Biitseva Angelina V.,
Rudenko Igor V.,
Hordiyenko Olga V.,
JamartGrégoire Brigitte,
Arrault Axelle
Publication year - 2012
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201200238
Subject(s) - isoindole , chemistry , peptidomimetic , amine gas treating , amino acid , peptide , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry
A variety of 1 H ‐isoindole‐based peptides was designed as potential mimics, and their efficient synthesis starting from 1‐imino‐1 H ‐isoindol‐3‐amine by subsequent interaction with N ‐Boc‐amino acid hydrazides and amino acid ester isocyanates generated in situ, followed by chain elongation using conventional peptide chemistry, was elaborated.